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  • Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04.

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04.

Organic & biomolecular chemistry (2019-02-21)
Fayrouz El Maddah, Ekaterina Eguereva, Stefan Kehraus, Gabriele M König
RESUMO

The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using 13C-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of a methylated acetate starter unit in polyketide biosynthesis, which is unique amongst fungal metabolites.

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Sigma-Aldrich
Sodium acetate-2-13C, 99 atom % 13C