G119

GYKI 52466 hydrochloride

solid

• Sinônimo(s): 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
• Fórmula empírica (Notação de Hill): C₁₇H₁₅N₃O₂ · HCl
• Número CAS: 192065-56-8
• Peso molecular: 329.78
• Número MDL: MFCD00153803
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277984
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• Formulário: solid
• cor: yellow
• solubilidade: DMSO: 0.39 mg/mL; ethanol: 0.4 mg/mL; 0.1 M HCl: 0.68 mg/mL; methanol: 1 mg/mL; H₂O: >10 mg/mL
• cadeia de caracteres SMILES: Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1
• InChI: 1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
• chave InChI: RUBSCPARMVJNKX-UHFFFAOYSA-N
• Informações sobre genes: human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Descrição

Aplicação

GYKI 52466 hydrochloride has been used as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). It has also been used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV) -induced motor neuron death.

Ações bioquímicas/fisiológicas

GYKI 52466 serves as an antagonist of several processes, mediated by glutamate.

Selective allosteric AMPA receptor antagonist; anti­convulsant; skeletal muscle relaxant.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações legais

Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves