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D8190

Sigma-Aldrich

3′,4′-Dichlorobenzamil hydrochloride

>98% (HPLC)

Sinônimo(s):

L-594,881

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About This Item

Fórmula empírica (Notação de Hill):
C13H12N7OCl3 · HCl
Número CAS:
928621-15-2
Peso molecular:
425.10
Número MDL:
MFCD03839362
Código UNSPSC:
12352200
ID de substância PubChem:
24278390
NACRES:
NA.77

Ensaio

>98% (HPLC)

forma

solid

cor

yellow

solubilidade

DMSO: soluble 30 mg/mL
H2O: insoluble

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl

InChI

1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H

chave InChI

LPHAOBPPRPXQLQ-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Friedrich Brunner et al.
Cardiovascular research, 60(2), 355-364 (2003-11-14)
The oxidant species peroxynitrite, the reaction product of nitric oxide (NO.) and superoxide, has been implicated in several pathophysiological conditions of the heart. Here, we studied the mechanism of peroxynitrite-induced cardiac depression using specific drugs and simultaneous analyses of myocardial
C Soto et al.
The Journal of experimental zoology, 289(1), 23-32 (2001-02-13)
The aim of this study was to analyze the relationship of the Na+/Ca2+ exchanger, cytosolic calcium, and chloride to the transepithelial transport of sodium in isolated frog skin. Sodium transport was measured as amiloride-inhibitable short circuit current (SCC). We studied
Shaminder Kaur et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(4), 435-443 (2009-04-02)
The present study was designed to investigate the possible neuroprotective effect of digoxin induced pharmacological preconditioning (PP) and its probable mechanism. Bilateral carotid artery occlusion (BCAO) of 17 min followed by reperfusion for 24 h was employed to produce ischemia
M N Sharikabad et al.
American journal of physiology. Heart and circulatory physiology, 280(1), H344-H353 (2000-12-21)
The effects of Mg(2+) on reactive oxygen species (ROS) and cell Ca(2+) during reoxygenation of hypoxic rat cardiomyocytes were studied. Oxidation of 2',7'-dichlorodihydrofluorescein (DCDHF) to dichlorofluorescein (DCF) and of dihydroethidium (DHE) to ethidium (ETH) within cells were used as markers
Toru Oda et al.
Journal of pharmacological sciences, 116(1), 128-131 (2011-04-28)
To elucidate the role of Na(+)/Ca(2+) exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX
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