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Documentos Principais

437R-1

Sigma-Aldrich

CD103 (EP206) Rabbit Monoclonal Primary Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP206, monoclonal

descrição

(For In Vitro Diagnostic Use in Select Regions (See Chart))

Formulário

buffered aqueous solution

reatividade de espécies

human

embalagem

bottle of 1.0 mL predilute (437R-17)
bottle of 7.0 mL predilute (437R-18)
vial of 0.1 mL concentrate (437R-14)
vial of 0.5 mL concentrate (437R-15)
vial of 1.0 mL concentrate (437R-16)

fabricante/nome comercial

Cell Marque®

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

Isotipo

IgG

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

Informações sobre genes

human ... ITGAE(3682)

Descrição geral

CD103 is an integrin subunit, αE, encoded by the ITGAE gene on chromosome 17.2 CD103 is expressed in almost all cases of hairy cell leukemia (HCL) and absent in the majority of other B-cell neoplasms with an exception to splenic marginal zone lymphoma, in which rare cases express CD103.1,2 CD103 has been found in mononuclear cells in the interfollicular area of lymph nodes and in intraepithelial cells in the overlying mucosa located primarily toward the basal layer of the tonsil.2 The high sensitivity of anti-CD103 for hairy cell leukemia makes this marker valuable when distinguishing from other B-cell neoplasms.

Qualidade


IVD

IVD

IVD

RUO

Ligação

CD103 Positive Control Slides, Product No. 437S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Elizabeth A Morgan et al.
American journal of clinical pathology, 139(2), 220-230 (2013-01-29)
Detection of the integrin subunit CD103 is a useful diagnostic tool in the diagnosis of hairy cell leukemia (HCL). Currently, flow cytometric analysis (FC) and frozen section immunohistochemistry (IHC) represent the only available methods of detection. This study is the
Henry Y Dong et al.
American journal of clinical pathology, 131(4), 586-595 (2009-03-18)
CD103 is characteristically expressed in hairy cell leukemia (HCL), a B-lymphoproliferative disorder highly responsive to treatment with purine analogs. Other CD103+ diseases are rare and do not respond well to the same therapy, including HCL variant (HCLv) and splenic marginal

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