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Merck
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Key Documents

MABN630

Sigma-Aldrich

Anti-SDHA Antibody, clone 7H11.2

clone 7H11.2, from mouse

Sinônimo(s):

Flavoprotein subunit of complex II, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

7H11.2, monoclonal

reatividade de espécies

human, mouse

técnica(s)

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG2aκ

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... SDHA(6389)

Descrição geral

SDHA, also known as Succinate dehydrogenase flavoprotein-mitochondrial subunit, or Flavoprotein subunit of complex II (Fp), and encoded by the gene symbol SDHA/ SDH2/ SDHF, is a member of the FAD-dependent oxidoreductase 2 family and the FRD/SDH subfamily. Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) is involved in the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Recent studies have indicated that SDHA may act as a tumor suppressor. SDHA is composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. SDHA interacts with SDHAF2/SDH5 in the process required for FAD attachment. Additionally, FDHA has been shown to interact with TRAP1. Mutations in the SDHA gene have been associated with Mitochondrial complex II deficiency (MT-C2D), a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Additionally, mutations in the SDHA gene have been implied in Leigh syndrome or Kearns-Sayre syndrome, Cardiomyopathy dilated 1GG (CMD1GG), and Paragangliomas 5 (PGL5).

Imunogênio

Epitope: Immunogen is near the C-terminal.
GST-tagged recombinant protein corresponding to the C-terminus of Human SDHA.

Aplicação

Anti-SDHA, clone 7H11.2 is an antibody against SDHA for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western Blotting Analysis: A 0.5 µg/mL dilution from a representative lot detected SDHA in 10 µg of C2C12 and HeLa cell lysates.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected SDHA in human cerebral cortex and human cardiac myocytes tissues.

Qualidade

Evaluated by Western Blotting in Human brain tissue lysate.

Western Blotting Analysis: A 0.5 µg/mL diultion of this antibody detected SDHA in 10 µg of Human brain tissue lysate.

Descrição-alvo

~68 kDa observed

forma física

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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