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Merck

SNCA

synuclein, alpha (non A4 component of amyloid precursor)

Sinônimos:
NACP, PARK1, PARK4, PD1
Espécies:
ID UniProtKB:
ID do gene:
  • Human(6622) Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(20617) synuclein, alpha
  • Rat(29219) synuclein, alpha (non A4 component of amyloid precursor)
  • chicken(395393) synuclein, alpha (non A4 component of amyloid precursor)
  • Horse(100053270) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic cat(101091694) synuclein, alpha (non A4 component of amyloid precursor)
  • dog(478478) synuclein, alpha (non A4 component of amyloid precursor)
  • cow(282857) synuclein, alpha (non A4 component of amyloid precursor)
  • sheep(100294604) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic guinea pig(100725375) synuclein, alpha (non A4 component of amyloid precursor)
  • naked mole-rat(101700039) synuclein, alpha (non A4 component of amyloid precursor)

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-phospho-α-synuclein (Ser129) Antibody, clone PS129, ,
Reatividade de espécies
bovine, human, mouse, porcine, rat
Aplicação
ELISA
immunohistochemistry

western blot
Anti-Aggregated a-Synuclein Antibody, clone 5G4, clone 5G4, from mouse, purified by affinity chromatography,
Reatividade de espécies
human
Aplicação
ELISA
immunohistochemistry

western blot
Anti-phospho-α-Synuclein (Ser129) Antibody, clone 81A, clone 81A, from mouse,
Reatividade de espécies
human, mouse
Aplicação
electron microscopy
immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-α-Synuclein antibody, Mouse monoclonal, clone Syn211, purified from hybridoma cell culture,
Reatividade de espécies
human, zebra finch
Aplicação
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-α-Synuclein Antibody, clone Syn211, ascites fluid, clone Syn211, Upstate®,
Reatividade de espécies
human
Aplicação
immunohistochemistry
immunoprecipitation (IP)

western blot

Proteins

Número do produto
Descrição
Espécies
α-Synuclein human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Espécies
human
Synuclein, α, recombinant human, ,
Espécies
human
α-Synuclein A53T human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Espécies
human
α-Synuclein, Human, Recombinant, E. coli, ,
Espécies
human
α-Synuclein E46K human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human SNCA (1),
Espécies
human
MISSION® esiRNA, targeting human SNCA (2),
Espécies
human