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Merck

NOS1

nitric oxide synthase 1 (neuronal)

Sinônimos:
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Espécies:
ID UniProtKB:
ID do gene:
  • Human(4842) Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
  • Mouse(18125) nitric oxide synthase 1, neuronal
  • Rat(24598) nitric oxide synthase 1, neuronal
  • Zebrafish(60658) nitric oxide synthase 1 (neuronal)
  • domestic cat(101100342) nitric oxide synthase 1 (neuronal)
  • cow(536132) nitric oxide synthase 1 (neuronal)
  • Horse(100051079) nitric oxide synthase 1 (neuronal)
  • dog(477498) nitric oxide synthase 1 (neuronal)
  • chicken(427721) nitric oxide synthase 1 (neuronal)
  • naked mole-rat(101711993) nitric oxide synthase 1 (neuronal)
  • Domestic Rabbit(100009243) nitric oxide synthase 1 (neuronal)
  • domestic guinea pig(100729682) nitric oxide synthase 1 (neuronal)

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Small Molecule - Antagonist

Número do produto
Descrição
Espécies
Ammonium pyrrolidinedithiocarbamate, ~99%,
Espécies
human
Melatonina, powder, ≥98% (TLC),
Espécies
human
Nω-Nitro-L-arginine, ≥98% (TLC),
Espécies
rat, mouse, human
Pentamidine isethionate salt, powder,
Espécies
human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Nitrotyrosine Antibody, Upstate®, from rabbit,
Reatividade de espécies
all
Aplicação
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Nitrotyrosine antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reatividade de espécies
wide range
Aplicação
ELISA
immunofluorescence

immunohistochemistry

microarray

western blot
Anti-Nitric Oxide Synthase I Antibody, serum, Chemicon®,
Reatividade de espécies
human, monkey, mouse, rat, sheep
Aplicação
immunohistochemistry
western blot
Anticorpo antinitrotirosina, Chemicon®, from rabbit,
Reatividade de espécies
all, human, mouse
Aplicação
immunohistochemistry
western blot
Anti-Nitrotyrosine Antibody, clone 1A6, clone 1A6, Upstate®, from mouse,
Reatividade de espécies
vertebrates
Aplicação
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
Spermidine trihydrochloride, ≥98% (TLC),
Espécies
human
4-Nitrocatechol, ≥96.0%,
Espécies
rat
5-Methyl-2-nitroaniline, 95%,
Espécies
rat
2,6-Di-tert-butyl-4-methylphenol, ≥99.0% (GC), powder,
Espécies
rat, human
L-Arginina, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%,
Espécies
rat, human

Kits

Número do produto
Descrição
Espécies
Nitric Oxide Synthase Detection System, Fluorimetric, sufficient for 200 reactions,
Espécies
human

Small Molecule - Precursor

Número do produto
Descrição
Espécies
L-Arginina, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%,
Espécies
rat, human
L-Arginina, ,
Espécies
rat, human
L-Arginina, 99%, FCC, FG,
Espécies
rat, human
L-Arginina, reagent grade, ≥98%,
Espécies
rat, human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting mouse Nos1,
Espécies
mouse