SRP6362
IL13RA2 human
recombinant, expressed in E. coli, ≥85% (SDS-PAGE)
Synonym(s):
CD213A2, CT19, IL-13R, IL13BP, Interleukin-13 receptor subunit alpha-2 precursor
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
Assay
≥85% (SDS-PAGE)
form
liquid
mol wt
39.5 kDa (340 aa, 27-343 aa + His Tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IL13RA2(3598)
General description
IL13Rα2 (interleukin 13 receptor subunit alpha 2) is a 42 kDa monomeric high affinity IL13 receptor. This gene is located on human chromosome Xq.
IL13RA2 is closely related to Il13RA1, a subunit of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. Recombinant human IL13RA2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Biochem/physiol Actions
IL-13Rα2 (interleukin 13 receptor subunit α 2) induces the progression, migration and invasion of glioma cells. It has the ability to initiate Scr (selective catalytic reduction), phosphatidylinositol 3 kinase (PI3K), Akt (signaling pathway) and mTOR (mammalian target of rapamycin). IL-13Rα2 chain plays a key role in IL-13 cytotoxin-mediated therapy. It is expressed at high levels in several human tumors such as oral squamous cell carcinoma, breast cancer, clear cell renal cell carcinoma, hepatic cell cancer, ovarian cancer and colorectal cancer.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway.
Tu M, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(11), 14701-14709 (2016)
Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers.
He JQ, et al.
American Journal of Respiratory Cell and Molecular Biology, 28(3), 379-385 (2003)
Interleukin-13 receptor α2 is associated with poor prognosis in patients with gastric cancer after gastrectomy.
Lin C, et al.
Oncotarget, 7(31), 49281-49281 (2016)
B Popovic et al.
Journal of molecular biology, 429(2), 208-219 (2016-12-14)
Interleukin (IL)-13 is a pleiotropic T helper type 2 cytokine frequently associated with asthma and atopic dermatitis. IL-13-mediated signalling is initiated by binding to IL-13Rα1, which then recruits IL-4Rα to form a heterodimeric receptor complex. IL-13 also binds to IL-13Rα2
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