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SRP0372

MKK6 active human

Name: MKK6 active human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Synonym(s):

MAP2K6, MEK6, mitogen-activated protein kinase kinase 6

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

63.5 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

1.36 mg/mL

NCBI accession no.

NM_002758.3

UniProt accession no.

P52564

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MAP2K6(5608)

General description

Human MKK6 (GenBank Accession No. NM_002758.3), amino acids 2-end with N-terminal GST-tag, MW=63.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.

Carlo Serra et al.

Molecular cell, 28(2), 200-213 (2007-10-30)

During muscle regeneration, the mechanism integrating environmental cues at the chromatin of muscle progenitors is unknown. We show that inflammation-activated MKK6-p38 and insulin growth factor 1 (IGF1)-induced PI3K/AKT pathways converge on the chromatin of muscle genes to target distinct components

Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia.

T L Lotan et al.

The Journal of pathology, 212(4), 386-394 (2007-06-20)

Identification of the signalling cascades that are differentially activated during prostatic tumourigenesis is a crucial step in the search for future molecular targets in this disease. The stress-activated protein kinase (SAPK) signalling cascade culminates in the phosphorylation of the JNK

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