SML3304
TP-040n
≥98% (HPLC)
Synonym(s):
4-(4-Methyl-1-piperazinyl)-N-(2-phenylethyl)-2-pyrimidinamine
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About This Item
Empirical Formula (Hill Notation):
C17H23N5
CAS Number:
Molecular Weight:
297.40
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN1CCN(C2=CC=NC(NCCC3=CC=CC=C3)=N2)CC1
Biochem/physiol Actions
TP-040n is an inactive control for TP-040 a brain penetrant, potent and selective inhibitor of O-GlcNAcase (OGA).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Michiko Tawada et al.
Journal of medicinal chemistry, 64(2), 1103-1115 (2021-01-07)
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokinetic profiles are desirable to characterize this enzyme. Herein, we report
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