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Key Documents

SML2906

Sigma-Aldrich

ERGi-USU

≥98% (HPLC)

Synonym(s):

1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol, 1-[2-Thiazolylazo]-2-naphthol, NSC139021, TAN

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About This Item

Empirical Formula (Hill Notation):
C13H9N3OS
CAS Number:
Molecular Weight:
255.30
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

faint brown to dark red

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H

InChI key

IOMXCGDXEUDZAK-UHFFFAOYSA-N

Biochem/physiol Actions

ERGi-USU is a selective and potent inhibitor of growth of ERG positive cancer cell lines, while spearing normal prostate or endothelial cells. It potently inhibits growth of ERG positive VCaP xenografts in mice. ERGi-USU is a potent and selective ligand of the ribosomal atypical kinase RIOK2 (right open reading frame (RIO) kinase 2) that induces ribosomal stress.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

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