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SML2299

Sigma-Aldrich

Photoregulin3

≥98% (HPLC)

Synonym(s):

2-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-6,7-dimethoxy-4(3H)-quinazolinone, PR3

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About This Item

Empirical Formula (Hill Notation):
C22H23N3O3
CAS Number:
785708-33-0
Molecular Weight:
377.44
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

OC(C1=C2)=NC(CN3CCC(C4=CC=CC=C4)=CC3)=NC1=CC(OC)=C2OC

InChI

1S/C22H23N3O3/c1-27-19-12-17-18(13-20(19)28-2)23-21(24-22(17)26)14-25-10-8-16(9-11-25)15-6-4-3-5-7-15/h3-8,12-13H,9-11,14H2,1-2H3,(H,23,24,26)

Biochem/physiol Actions

Photoregulin3 is a modulator of the rod transcription factor Nr2e3 that inhibits rod photoreceptor gene expression. Photoregulin3 significantly rescues photoreceptor in RhoP23H mice.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Paul A Nakamura et al.
eLife, 6 (2017-11-18)
Regulation of rod gene expression has emerged as a potential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP). We previously reported on a small molecule modulator of the rod transcription factor Nr2e3, Photoregulin1 (PR1), that regulates the

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