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SML0296

Sigma-Aldrich

Pyroxamide

≥97% (HPLC)

Synonym(s):

N1-Hydroxy-N8-3-pyridinyl-octanediamide

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About This Item

Empirical Formula (Hill Notation):
C13H19N3O3
CAS Number:
382180-17-8
Molecular Weight:
265.31
MDL number:
MFCD13194970
UNSPSC Code:
12352200
PubChem Substance ID:
329825303
NACRES:
NA.77

Quality Level

100

Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

ONC(=O)CCCCCCC(=O)Nc1cccnc1

InChI

1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)

InChI key

PTJGLFIIZFVFJV-UHFFFAOYSA-N

Biochem/physiol Actions

Pyroxamide is an inhibitor of HDAC1 (IC50 = 100 nM). Pyroxamide induces apoptosis and cell cycle arrest in leukemia, bladder and prostate cancer cell lines.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yunwei Guo et al.
Acta pharmaceutica Sinica. B, 10(5), 825-836 (2020-06-13)
The transcription factor nuclear factor kappa B (NF-κB) is activated in hepatocytes in the pathogenesis of hepatic steatosis. However, the action mechanism of NF-κB remains to be established in the hepatic steatosis. In this study, the P50 subunit of NF-κB
Michael S Werner et al.
Nature communications, 14(1), 2095-2095 (2023-04-14)
Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown.
Angela K Carrillo et al.
Bioorganic & medicinal chemistry, 23(16), 5151-5155 (2015-02-01)
Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDACi) for their ability to block proliferation of Trypanosoma brucei

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