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About This Item
Empirical Formula (Hill Notation):
C42H74N12O14S1
CAS Number:
Molecular Weight:
1003.17
UNSPSC Code:
12352209
NACRES:
NA.32
Amino Acid Sequence
Gly-Ser-Asn-Ala-Gly-Ala-Ile-Ile-Gly-Leu-Met
General description
β-Amyloid peptides are a major component of the senile placques characteristic of the Alzheimer brain. Aβ (25-35) represents the region that aggregates during placque formation in Alzheimer′s disease and is a functional domain implicated in both neurotrophic and neurotoxic effects. Substitutions in this sequence can contribute to an understanding of structural characteristics related to membrane insertion, aggregation and protfibril formation with subsequent neurotoxic effects.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Hui-Hsu Gavin Tsai et al.
Proteins, 78(8), 1909-1925 (2010-03-17)
The mechanisms of interfacial folding and membrane insertion of the Alzheimer's amyloid-beta fragment Abeta(25-35) and its less toxic mutant, N27A-Abeta(25-35) and more toxic mutant, M35A-Abeta(25-35), are investigated using replica-exchange molecular dynamics in an implicit water-membrane environment. This study simulates the
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