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Key Documents

SAB4300538

Sigma-Aldrich

Anti-GRIN1 (Ab-897) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-NMDA1 antibody produced in rabbit, Anti-NMDAR1 antibody produced in rabbit, Anti-NR1 antibody produced in rabbit, Anti-glutamate receptor, ionotropic, N-methyl D-aspartate 1 antibody produced in rabbit

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About This Item

MDL number:
MFCD00282329
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~120 kDa

species reactivity

human, mouse, rat

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200

isotype

IgG

immunogen sequence

(R-S-S-K-D)

NCBI accession no.

NP_000823.4

UniProt accession no.

Q05586

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRIN1(2902)

Immunogen

Peptide sequence around aa. 895-899 (R-S-S-K-D), according to the protein GRIN1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wei Guo et al.
Molecular pain, 10, 35-35 (2014-06-11)
It has been recently recognized that the descending serotonin (5-HT) system from the rostral ventromedial medulla (RVM) in the brainstem and the 5-HT3 receptor subtype in the spinal dorsal horn are involved in enhanced descending pain facilitation after tissue and
Yu-Wen Chen et al.
Regional anesthesia and pain medicine, 39(4), 322-328 (2014-05-02)
Transcutaneous electrical nerve stimulation (TENS) is a common therapeutic modality for pain management, but its effectiveness in skin/muscle incision and retraction (SMIR)-evoked pain is unknown. We aimed to examine the effects of TENS on postoperative pain and the levels of
Zhenglin Gu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(41), 13614-13628 (2014-10-10)
Degeneration of basal forebrain (BF) cholinergic neurons is one of the early pathological events in Alzheimer's disease (AD) and is thought to be responsible for the cholinergic and cognitive deficits in AD. The functions of this group of neurons are
Su-Bo Yuan et al.
Annals of neurology, 75(6), 837-850 (2014-03-19)
Chronic pain is a common neurological comorbidity of human immunodeficiency virus (HIV)-1 infection, but the etiological cause remains elusive. The objective of this study was to identify the HIV-1 causal factor that critically contributes to the pathogenesis of HIV-associated pain.

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