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Key Documents

COO/COA

SAB2500278

Anti-CSNK1E antibody produced in goat

Name: Anti-CSNK1E antibody produced in goat
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Casein kinase 1, Anti-HCKIE, Anti-MGC10398, Anti-RP1-5O6.1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse, canine

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P49674

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CSNK1E(1454)

General description

Casein kinase 1 ε (CSNK1E) is part of the serine/threonine protein kinase family. The gene encoding it is localized on human chromosome 22q13.1.

Immunogen

Peptide with sequence C-PASQTSVPFDHLGK from the C Terminus of the protein sequence according to NP_001885.1; NP_689407.1.

Biochem/physiol Actions

Casein kinase 1 ε (CSNK1E) phosphorylates proteins of the Wnt signaling cascade. It modulates tumor growth and cell division in salivary gland cancer, pancreatic and colon adenocarcinoma cells. CSNK1E phosphorylates dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) and modulates dopamine receptor signaling. It also interacts with proteins involved in circadian rhythm.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315 - H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.

Takahisa Kuga et al.

Scientific reports, 6, 26557-26557 (2016-05-26)

FAM83H is essential for the formation of dental enamel because a mutation in the FAM83H gene causes amelogenesis imperfecta (AI). We previously reported that the overexpression of FAM83H often occurs and disorganizes the keratin cytoskeleton in colorectal cancer cells. We

Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis.

Kumar A, et. al

Genomics, 90(5), 559-566 (2007)

Association between a casein kinase 1 e gene polymorphism and schizophrenia in a Chinese Han population.

Huang Y

Journal of Molecular Neuroscience, 47(3), 470-474 (2012)

Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants.

Levran O

Pharmacogenomics, 15(16), 2001-2009 (2014)