N3510
Niclosamide
Synonym(s):
2′,5-Dichloro-4′-nitrosalicylanilide
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About This Item
Empirical Formula (Hill Notation):
C13H8Cl2N2O4
CAS Number:
Molecular Weight:
327.12
Beilstein:
2820605
EC Number:
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
Recommended Products
form
powder
Quality Level
antibiotic activity spectrum
parasites
Mode of action
enzyme | inhibits
SMILES string
Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
InChI
1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI key
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
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Application
Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.
Biochem/physiol Actions
Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.
Other Notes
50g,250g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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