C9033
β-Chloro-L-alanine hydrochloride
Alanine aminotransferase inhibitor
Synonym(s):
(R)-2-Amino-3-chloropropanoic acid, 3-Chloro-L-alanine
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About This Item
Empirical Formula (Hill Notation):
C3H6ClNO2 · HCl
CAS Number:
Molecular Weight:
160.00
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Recommended Products
biological source
synthetic
Quality Level
Assay
≥98% (TLC)
form
powder
mp
205 °C
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl[H].N[C@@H](CCl)C(O)=O
InChI
1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
InChI key
IENJPSDBNBGIEL-DKWTVANSSA-N
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Application
β-Chloro-L-alanine hydrochloride has been used:
- as a substrate for screening tyrosine phenol lyase steady state kinetics
- in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells
- as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system
Biochem/physiol Actions
β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Serine 51 residue of Citrobacter freundii tyrosine phenol-lyase assists in C-alpha-proton abstraction and transfer in the reaction with substrate
Barbolina MV, et al.
Biochimie, 147(1), 63-69 (2018)
Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133
Song Y, et al.
Scientific Reports, 8(1), 16100-16100 (2018)
Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells: a novel evaluation system using an SPT-defective mammalian cell mutant
Hanada K, et al.
Biochemical Pharmacology, 59(10), 1211-1216 (2000)
A novel way of amino acid-specific assignment in 1 H-15 N HSQC spectra with a wheat germ cell-free protein synthesis system
Morita EH, et al.
Journal of Biomolecular Nmr, 30(1), 37-45 (2004)
Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
Beuster G, et al.
The Journal of Biological Chemistry, jbc-M110 (2011)
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