A4626
1-Acetyl-2-phenylhydrazine
≥98%
Synonym(s):
N-Acetyl-N′-phenylhydrazine, acetylphenylhydrazine
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About This Item
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Quality Level
Assay
≥98%
form
(Powder with Chunk(s) or Crystals with Chunk(s))
mp
128-131 °C (lit.)
SMILES string
CC(=O)NNc1ccccc1
InChI
1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)
InChI key
UICBCXONCUFSOI-UHFFFAOYSA-N
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Application
1-Acetyl-2-phenylhydrazine (AcPhHZ) which reacts with oxyhaemoglobin to form free radicals may be used to induce haemolytic anaemia for studies of the hematopoietic system.
Biochem/physiol Actions
1-Acetyl-2-phenylhydrazine (AcPhHZ) is a vascular tumor initiator used in experimental animal model.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Journal of cell science, 94 ( Pt 3), 593-600 (1989-11-01)
An unusual form of red cells (called sequestrocytes) that circulate in the peripheral blood of patients with sickle cell anemia has been identified. In wetmount light microscopy preparations, sequestrocytes appear as massively vacuolated erythrocytes. We have shown by transmission electron
Biochemical medicine and metabolic biology, 45(1), 16-27 (1991-02-01)
After in vitro treatment of normal, glucose-6-phosphate dehydrogenase-deficient or pyruvate kinase-deficient human erythrocytes with three different oxidizing agents, the extent of lipid peroxidative degradation and the alterations of membrane proteins were evaluated. Exposure to tert-butylhydroperoxide induced, most markedly in G6PD-
American journal of veterinary research, 54(4), 622-626 (1993-04-01)
To clarify the oxidant defense functions of reduced glutathione (GSH) in erythrocytes, the effect of GSH deficiency on in vitro oxidant defense was studied, using GSH-deficient sheep erythrocytes (low-GSH cells). The formation of Heinz bodies in low-GSH cells was higher
Biochimica et biophysica acta, 1568(1), 99-104 (2001-12-04)
The oxidative action of acetylphenylhydrazine (APH) on red blood cells obtained from healthy donors and from patients with breast cancer has been investigated by Mössbauer spectroscopy. Whole blood was incubated with APH for different time periods and the Mössbauer spectra
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(18), 2543-2547 (2012-01-20)
To investigate Siwu decoction and its composite drugs on the blood-deficiency model mice induced by acetylphenyhydrazine and cyclophosphamide. Acetylphenyhydrazine and cyclophosphamide were used to copy the blood-deficiency model mice. Automatic hematology analyzer was used to test the peripheral hemogram. Weighting
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