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Key Documents

COO/COA

Oxcarbazepine

Name: Oxcarbazepine
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide, Oxacarbazepine

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₂N₂O₂

CAS Number:

28721-07-5

Molecular Weight:

252.27

MDL number:

MFCD00865307

UNSPSC Code:

41116107

PubChem Substance ID:

329831491

NACRES:

NA.24

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Supelco

O-039

Oxcarbazepine-¹³C₆ solution

Y0001014

Amphotericin B for peak identification

Sigma-Aldrich

A5512

Aristolochic acid I

Y0000386

Foeniculin for peak identification

Sigma-Aldrich

5.08508

Zonisamide

Y0001044

Oxymetazoline impurity A

Y0000272

Oxaliplatin impurity B

S859613

2-(ANILINOMETHYL)PHENOL

grade

pharmaceutical primary standard

API family

oxcarbazepine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C1CC2=C(C=CC=C2)N(C(N)=O)C3=CC=CC=C31

InChI

1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)

InChI key

CTRLABGOLIVAIY-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Related Categories

Analytical Reference Materials for the Pharma Industry

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Oxcarbazepine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Anticonvulsant, antineuralgic. Inhibits veratrine-induced transmitter release.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Safety and efficacy of anticonvulsants in elderly patients with psychiatric disorders: oxcarbazepine, topiramate and gabapentin.

Barbara R Sommer et al.

Expert opinion on drug safety, 6(2), 133-145 (2007-03-21)

Few controlled studies are available to guide the clinician in treating potentially assaultive elderly individuals with psychiatric disorders. Safety concerns limit the use of benzodiazepines and antipsychotic medications in the elderly individual, making anticonvulsants an attractive alternative. This paper reviews

Oxcarbazepine for acute affective episodes in bipolar disorder.

Akshya Vasudev et al.

The Cochrane database of systematic reviews, (12)(12), CD004857-CD004857 (2011-12-14)

Oxcarbazepine, a keto derivative of the 'mood stabiliser' carbamazepine, may have efficacy in the treatment of acute episodes of bipolar disorder. Potentially, it may offer pharmacokinetic advantages over carbamazepine. To review the efficacy and acceptability of oxcarbazepine compared to placebo

Oxcarbazepine in the maintenance treatment of bipolar disorder.

A Vasudev et al.

The Cochrane database of systematic reviews, (1)(1), CD005171-CD005171 (2008-02-07)

Some studies have suggested that oxcarbazepine has a role in preventing episode recurrence in bipolar affective disorder. This review attempted to investigate the existing evidence from randomised controlled trials for its use in the maintenance treatment of this illness. To

Oxcarbazepine in bipolar disorder: a critical review of the literature.

Marianna Mazza et al.

Expert opinion on pharmacotherapy, 8(5), 649-656 (2007-03-23)

Oxcarbazepine (OXC) is a keto-congener of carbamazepine, which has fewer side effects and drug interactions. However, the efficacy of OXC in treating bipolar disorder is not as well established as that of carbamazepine. This article is a systematic literature review

Oxcarbazepine for refractory epilepsy: systematic review of the literature.

Humberto Saconato et al.

Sao Paulo medical journal = Revista paulista de medicina, 127(3), 150-159 (2009-10-13)

It has been estimated that 50 million people worldwide suffer from epilepsy and around 30% will not achieve adequate control over the disease. The aim was to evaluate the effectiveness of oxcarbazepine for refractory partial or generalized epilepsy. Systematic review.

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