SMB01318

3-Hydroxydesloratadine

• Synonym(s): 3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
• Empirical Formula (Hill Notation): C₁₉H₁₉ClN₂O
• CAS Number: 119410-08-1
• Molecular Weight: 326.82
• MDL number: MFCD00878381
• NACRES: NA.77

Properties

• description: Modulation and Signaling
• Quality Level: 100
• Assay: ≥90%
• form: solid
• technique(s): HPLC: suitable
• color: pale yellow to off-white
• storage temp.: −20°C
• InChI: 1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
• InChI key: NDFMTPISBHBIKE-UHFFFAOYSA-N

Description

General description

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

Application

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

Biochem/physiol Actions

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

Features and Benefits

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

Other Notes

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This product is intended for research purposes only, and it is not meant for human consumption.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable