00900585

Berberine chloride

primary reference standard

• Synonym(s): Berberine chloride form, Natural Yellow 18
• Empirical Formula (Hill Notation): C₂₀H₁₈ClNO₄
• CAS Number: 633-65-8
• Molecular Weight: 371.81
• Colour Index Number: 75160
• Beilstein: 3836585
• MDL number: MFCD00011939
• UNSPSC Code: 12352210
• NACRES: NA.24

Properties

• grade: primary reference standard
• Quality Level: 100
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: HWI
• SMILES string: COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]
• InChI: 1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
• InChI key: VKJGBAJNNALVAV-UHFFFAOYSA-M

Description

General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable