SCC262

SK-MEL-37 Human Melanoma Cell Line

• UNSPSC Code: 41106514

Properties

• biological source: human
• Quality Level: 100
• packaging: vial of >1X10⁶ cells
• manufacturer/tradename: Millipore
• growth mode: N/A
• technique(s): cell culture | mammalian: suitable
• shipped in: liquid nitrogen
• storage temp.: −196°C

Description

Application

• Each vial contains > 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
• Cells are negative for mycoplasma contamination.

Malignant melanoma is the most aggressive type of skin cancer, and the fifth most common cancer in the Unites States.1 As survival rate depends on the stage of disease at time of diagnosis, early detection is crucial to improving disease outcome and saving lives. Amelanotic (or hypomelanotic) melanoma (AM) is a rare subtype of cutaneous melanoma, comprising between 2-8% of total cases.2 AM is characterized by decreased or null presence of melanin, due to loss of pigment in tumor evolution. AM is usually diagnosed at more advanced stages, resulting in lower overall survival. AM is frequently observed in patients with melanocortin 1 receptor gene (MC1R) genotypes linked to certain phenotypes such as red hair.2
The SK-MEL-37 amelanotic cutaneous melanoma cell line is a well-established model for human melanoma, widely utilized in investigations into the mutational landscape of melanoma and the enhanced antigen expression that occurs concomitantly with melanoma progression. SK-MEL-37 expresses the melanoma-associated antigens MAGE-A1, tyrosinase, and p97, and cell surface antigens essential for metastasis such as CD71 and CD146.3 SK-MEL-37 is valuable and highly characterized cell system for transformation of melanocytes into melanoma and identification of therapeutic targets for this disease.

Source
SK-MEL-37 was established from a metastatic lymph node of a 65-year old male patient with malignant melanoma of rectal tumor origin.4

References
1. CA Cancer J Clin 2019, 69(1): 7-34.
2. Cancers (Basel) 2020, 12(9): 2362.
3. J Cancer 2013, 45(5): 371-382.
4. J Exp Med 1976, 144(4): 873

Features and Benefits

SK-MEL-37 is valuable and highly characterized cell system for transformation of melanocytes into melanoma and identification of therapeutic targets for this disease.

Storage and Stability

The cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting functionality.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable