1.00574

1-Methyl-2-pyrrolidone

for Peptide Synthesis

• Synonym(s): 1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone
• Empirical Formula (Hill Notation): C₅H₉NO
• CAS Number: 872-50-4
• Molecular Weight: 99.13
• MDL number: MFCD00003193
• UNSPSC Code: 12352115
• EC Index Number: 212-828-1

Properties

• vapor pressure: 0.32 hPa ( 20 °C)
• Quality Level: 200
• Assay: ≥99.7% (GC)
• form: liquid
• autoignition temp.: 245 °C
• potency: 3598 mg/kg LD₅₀, oral (Rat); 8000 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 1.3-9.5 % (v/v)
• pH: 8.5-10.0 (20 °C, 100 g/L in H₂O)
• bp: 202 °C/1013 hPa
• mp: -24 °C
• transition temp: flash point 91 °C
• density: 1.03 g/cm³ at 20 °C
• application(s): peptide synthesis
• storage temp.: 2-30°C
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• InChI key: SECXISVLQFMRJM-UHFFFAOYSA-N

Description

General description

N-methyl-2-pyrrolidone (NMP) is an organic solvent that finds applications in numerous industries, including petrochemicals, plastics, microelectronics, and to produce pigments, cosmetics, and drugs. It is commonly used worldwide as an organic solvent, intermediate, or surfactant in various industrial and consumer applications. The unique characteristics of NMP, including its ability to mix with water and organic solvents, and its temperature, polarity, and composition stability, make it a solvent of great interest in extractive distillation.

Application

1-Methyl-2-pyrrolidone can be used as a solvent during the peptide bond formation reactions.

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H315 - H319 - H335 - H360D
• Precautionary Statements: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point(F): 195.8 °F - Pensky-Martens closed cup
• Flash Point(C): 91 °C - Pensky-Martens closed cup