857127P

17:0 Lyso PA

1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), powder

• Synonym(s): heptadecanoyl lysophosphatidic acid; 1-heptadecanoyl-sn-glycero-3-phosphate (sodium salt); PA(17:0/0:0); 17:0 LPA; 110679
• Empirical Formula (Hill Notation): C₂₀H₄₀O₇PNa
• CAS Number: 799268-66-9
• Molecular Weight: 446.49
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• Assay: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• form: powder
• packaging: pkg of 1 × 25 mg (857127P-25mg)
• manufacturer/tradename: Avanti Polar Lipids 857127P
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100 nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.

Application

17:0 Lyso PA is suitable to use as an internal standard:

• for mass spectrometric determination of lysophosphatidic acid molecular species in mouse peritoneal macrophages
• in the quantification of the lipid species released from extended synaptotagmin 2 (E-SYT2) expressed in mammalian cells by liquid chromatography with tandem mass spectrometry (LC-MS/MS)
• for the extraction of lipids from brain homogenate
• to extract lipids from the stomach washing solution for the determination of lysophosphatidic acid in a mouse stomach fluid

Biochem/physiol Actions

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).

Packaging

5 mL Amber Glass Screw Cap Vial (857127P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): No data available
• Flash Point(C): No data available