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906840

Sigma-Aldrich

Poly(L-lactide-co-caprolactone)

lactide:caprolactone 90:10, viscosity 1.7 dL/g 

Synonym(s):

PCL-PLLA, PLLA-PCL

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About This Item

Linear Formula:
CH3(C6H10O2)m(C6H8O4)nCH3
UNSPSC Code:
12162002

form

chunks

feed ratio

lactide:caprolactone 90:10

color

white to off-white

viscosity

1.7 dL/g

storage temp.

−20°C

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General description

Poly(L-lactide-co-caprolactone) (PCL-PLLA) is a biodegradable polymer which can be synthesized by bulk ring-opening copolymerization of L-lactide and ε-caprolactone. Its properties include flexibility, biocompatibility and controlled degradation process.

Application

PCL-PLLA can be used for a variety of applications such as tissue engineering, bone fixation devices and surgical sutures.
Poly(L-lactide-co-caprolactone) (PLLA-PCL) is a biodegradable copolymer. poly(L-lactide) exhibits a high modulus and has been often copolymerized with PCL to improve the mechanical properties of PCL, and increase degradation rate of the resulting polymer. PLLA-PCL has been used in tissue engineering, 3D bioprinting and drug delivery research applications.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Comparison of plasma and chemical modifications of poly-L-lactide-co-caprolactone scaffolds for heparin conjugation
Hsieh Y, et al.
Bio-medical materials and engineering, 12(6), 065004-065004 (2017)
Preclinical animal study and human clinical trial data of co-electrospun poly (L-lactide-co-caprolactone) and fibrinogen mesh for anterior pelvic floor reconstruction
Wu X, et al.
International journal of nanomedicine, 11(6), 389-389 (2016)
Fabrication and characterization of vitamin B5 loaded poly (l-lactide-co-caprolactone)/silk fiber aligned electrospun nanofibers for schwann cell proliferation
Bhutto MA, et al.
Colloids and Surfaces. B, Biointerfaces, 144(6), 108-117 (2016)
Preparation of a poly (L-lactide-co-caprolactone) copolymer using a novel tin (II) alkoxide initiator and its fiber processing for potential use as an absorbable monofilament surgical suture
Ruengdechawiwat S, et al.
International Journal of Polymeric Materials and Polymeric Biomaterials, 65(6), 277-284 (2016)
Application of a bilayer tubular scaffold based on electrospun poly (L-lactide-co-caprolactone)/collagen fibers and yarns for tracheal tissue engineering
Wu T, et al.
Journal of materials chemistry. B, 5(1), 139-150 (2017)

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