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100013

Sigma-Aldrich

4,4′-Dimethoxytrityl chloride

95%

Synonym(s):

DMT-Cl

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About This Item

Linear Formula:
C6H5C(C6H4OCH3)2Cl
CAS Number:
40615-36-9
Molecular Weight:
338.83
Beilstein:
2471942
EC Number:
255-002-6
MDL number:
MFCD00008409
UNSPSC Code:
12352101
PubChem Substance ID:
24846511
NACRES:
NA.22

Assay

95%

form

solid

mp

119-123 °C (lit.)

SMILES string

COc1ccc(cc1)C(Cl)(c2ccccc2)c3ccc(OC)cc3

InChI

1S/C21H19ClO2/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18/h3-15H,1-2H3

InChI key

JBWYRBLDOOOJEU-UHFFFAOYSA-N

General description

DMT-Cl is commonly used as a protecting group for various functional groups in organic synthesis.

Application

Hydroxyl protecting group for nucleosides and nucleotides.

Signal Word

Danger

Hazard Statements

H314,H317,H335,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Y Ueno et al.
Nucleic acids research, 21(19), 4451-4457 (1993-09-25)
The preparation of a nucleotidyl-peptide having a thymidine-5'-yl-(P-O)-serine phosphodiester bond, [H-Ala-Ser(pTpT)-Phe-OH](24) is described. After condensation between the phosphorylated peptide component and an oligonucleotide component, all protecting groups could be removed under neutral conditions without beta-elimination of the pTpT from the
Journal of the American Chemical Society, 115, 4985-4985 (1993)
T Tuschl et al.
Biochemistry, 32(43), 11658-11668 (1993-11-02)
The three guanosines of the central core of a hammerhead ribozyme were replaced by 2-aminopurine ribonucleoside, xanthosine, isoguanosine, inosine, and deoxyguanosine. These analogues were incorporated by automated solid-phase synthesis, with the exception of isoguanosine. This was introduced by ligating a
Thomas F Scott et al.
Clinical neurology and neurosurgery, 127, 86-92 (2014-12-03)
To describe a "new natural history" of multiple sclerosis (MS), characterizing three patterns of progression in Relapsing MS (RMS) patients during the "treatment era," using newly developed definitions. By utilizing our simple model we intend to predict which patients are
Yuzhe Du et al.
Molecular pharmacology, 88(2), 273-280 (2015-05-15)
Voltage-gated sodium channels are the primary target of pyrethroid insecticides. Although it is well known that specific mutations in insect sodium channels confer knockdown resistance (kdr) to pyrethroids, the atomic mechanisms of pyrethroid-sodium channel interactions are not clearly understood. Previously
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