BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
Synonyms:
BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP
Species:
Human BTRC (8945), Mouse Btrc (12234), Rat Btrc (361765), chicken BTRC (423854), dog BTRC (486851), cow BTRC (534072), domestic cat BTRC (101097596), Horse BTRC (100070200), sheep BTRC (101101939), Domestic Rabbit BTRC (100350519) ...More
UniProtKB ID:
Gene ID:
- Human(8945) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
- Mouse(12234) beta-transducin repeat containing protein
- Rat(361765) beta-transducin repeat containing E3 ubiquitin protein ligase
- chicken(423854) beta-transducin repeat containing
- dog(486851) beta-transducin repeat containing E3 ubiquitin protein ligase
- cow(534072) beta-transducin repeat containing
- domestic cat(101097596) beta-transducin repeat containing E3 ubiquitin protein ligase
- Horse(100070200) beta-transducin repeat containing E3 ubiquitin protein ligase
- sheep(101101939) beta-transducin repeat containing E3 ubiquitin protein ligase
- Domestic Rabbit(100350519) beta-transducin repeat containing E3 ubiquitin protein ligase
- naked mole-rat(101726740) beta-transducin repeat containing E3 ubiquitin protein ligase
- domestic guinea pig(100730107) beta-transducin repeat containing E3 ubiquitin protein ligase
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Antibodies
Product Number
Description
Species Reactivity
Application
ANTI-BTRC (N-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-BTRC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
ANTI-BRTC1/2(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
esiRNA
Product Number
Description
Species