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Synthesis of novel, potentially biologically active dibenzosuberone derivatives.

Molecules (Basel, Switzerland) (2007-11-17)
Sonja Merkas, Mladen Litvić, Ivica Cepanec, Vladimir Vinković
RÉSUMÉ

Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many countries.

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Dibenzosuberone, European Pharmacopoeia (EP) Reference Standard
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