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Synthesis of taurine analogues from alkenes: preparation of 2-aminocycloalkanesulfonic acids.

Advances in experimental medicine and biology (2002-01-15)
F Machetti, M Cacciarini, F Catrambone, F M Cordero, M Frosini, F De Sarlo
RÉSUMÉ

(+/-)trans 2-Aminocyclohexanesulfonic acid and (+/-)trans 2-aminocyclopentanesulfonic acid were prepared from cyclohexene and cyclopentene respectively by sulfur monochloride addition, followed by oxidation to 2-chlorosulfonic acid and substitution of chlorine.

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Sigma-Aldrich
Chlorosulfonic acid, 99%
Sigma-Aldrich
Sulfur monochloride, 98%