- Ligand effects on the stereochemical outcome of Suzuki-Miyaura couplings.
Ligand effects on the stereochemical outcome of Suzuki-Miyaura couplings.
The Journal of organic chemistry (2012-04-07)
Guo-Ping Lu, Karl R Voigtritter, Chun Cai, Bruce H Lipshutz
PMID22480237
RÉSUMÉ
The ligands associated with various Pd catalysts play a crucial role in determining the stereochemistry of cross-couplings between boronic acids and Z-alkenyl halides. A ligand on palladium has been found that leads to the desired products under mild conditions and in high yields that, in most cases, retain their Z-olefin geometry.
MATÉRIAUX