- IRAK-4 inhibitors. Part 1: a series of amides.
IRAK-4 inhibitors. Part 1: a series of amides.
Bioorganic & medicinal chemistry letters (2008-05-14)
George M Buckley, Lewis Gowers, Alicia Perez Higueruelo, Kerry Jenkins, Stephen R Mack, Trevor Morgan, David M Parry, William R Pitt, Oliver Rausch, Marianna D Richard, Verity Sabin, Joanne L Fraser
PMID18474425
RÉSUMÉ
The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.
MATÉRIAUX