Chiral Catalysts & Ligands

The quest for novel, efficient chiral catalysts and ligands for enantiopure molecules is an ongoing endeavor in the pharmaceutical, flavors and fragrances, and agrochemical industries. Nearly 85% of new drugs in the market are chiral. This need has led to developments in asymmetric synthesis of chiral ligands and metal complexes. In 2001, the Nobel Prize rewarded the pioneering work of Knowles, Noyori, and Sharpless in the development of catalytic asymmetric synthesis, highlighting the importance of chiral synthesis in chemistry. With the pioneering work of Noyori in the 1980s with BINAP ligands, began an era where catalysts and ligands became more effective and selective. Hydroformylation, hydrogenation, and cross-coupling are some of the more popular applications using chiral ligands.

Asymmetric Catalysis Privileged Ligands and Complexes

The quest for novel, efficient chiral transition metal catalysts has been an ongoing endeavor for the past 40 years.

Highly effective asymmetric catalytic systems give access to arrays of chiral building blocks used in the synthesis of natural products and drugs. Among the plethora of chiral ligands, a few stand out because of their versatility. The common feature of these “privileged” ligands is their C2 symmetry, reducing the number of possible isomeric metal complexes and the number of different substrates. Among the most recognized family of chiral ligands, BINAP, salens, bisoxazolines, tartrate ligands, and cinchona alkaloids represent the original “privileged ligands” classes that affect a wide variety of transformations under outstanding enantiocontrol and with high yield. A second wave of privileged ligands has surfaced with the DuPhos phospholanes, DSM phosphoramidites, Solvias Josiphos families, the Reetz and Trost ligands, and ChiralQuest phosphines. These outstanding ligand families have proven their success in industrially useful reactions such as hydrogenations, aldol reactions, and asymmetric allylic alkylations, and gained much attention from the synthetic community due to their ready accessibility and modular nature of their design.