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Merck

SLC6A2

solute carrier family 6 (neurotransmitter transporter), member 2

Synonymes:
NAT1, NET, NET1, SLC6A5
Espèce(s):
Human SLC6A2 (6530), Mouse Slc6a2 (20538), Rat Slc6a2 (83511), chicken SLC6A2 (395458), dog SLC6A2 (487272), domestic cat SLC6A2 (493768), Horse SLC6A2 (100061346), domestic cat SLC6A2 (101099605), cow SLC6A2 (282363), sheep SLC6A2 (443100) ...Plus
ID UniProtKB:
P23975, B2R707, Q96KH8
ID du gène:
  • Human(6530) Summary: This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
  • Mouse(20538) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • Rat(83511) solute carrier family 6 (neurotransmitter transporter), member 2
  • chicken(395458) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • dog(487272) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • domestic cat(493768) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • Horse(100061346) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • domestic cat(101099605) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • cow(282363) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • sheep(443100) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • sheep(101116078) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • Domestic Rabbit(100328959) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • naked mole-rat(101716834) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • domestic guinea pig(100723578) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

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Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
32950
4,4′-Diaminodiphenylmethane, ≥97.0% (GC),
Espèce(s)
mouse, rat
N5536
Nefazodone hydrochloride, ≥98% (HPLC), solid,
Espèce(s)
human
1457902
Nefazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1031401
Amoxapine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
A-123
Amoxapine, 1.0 mg/mL in methanol, certified reference material, Cerilliant®,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
AB120
Anti-Norepinephrine Antibody, serum, Chemicon®,
Espèces réactives
human, rat
Application
immunohistochemistry
SAB2108224
Anti-SLC6A2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
HPA076311
Anti-SLC6A2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry
SAB2109032
Anti-SLC6A2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, canine, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
AB5066P
Anticorps anti-transporteur de norépinéphrine, Chemicon®, from rabbit,
Espèces réactives
mouse, rat
Application
ELISA
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
D3900
Desipramine hydrochloride, ≥98% (TLC), powder,
Espèce(s)
human
D-906
Desipramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
D1306
Debrisoquine sulfate, ,
Espèce(s)
human
1044469
Atomoxetine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
M-920
Maprotiline hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU097611
MISSION® esiRNA, targeting human SLC6A2,
Espèce(s)
human

Small Molecule - Substrate

Référence du produit
Description
Espèce(s)
1301801
Guanethidine monosulfate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1076352
Bretylium tosylate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
BP181
Guanethidine monosulfate, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human