SHC1
SHC (Src homology 2 domain containing) transforming protein 1
Synonymes:
SHC, SHCA
Espèce(s):
Human SHC1 (6464), Mouse Shc1 (20416), Rat Shc1 (85385), Zebrafish shc1 (323818), dog SHC1 (490439), Horse SHC1 (100063053), domestic cat SHC1 (101092911), chicken SHC1 (395934), cow SHC1 (507196), sheep SHC1 (101113548) ...Plus
ID UniProtKB:
ID du gène:
- Human(6464) Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Mouse(20416) src homology 2 domain-containing transforming protein C1
- Rat(85385) SHC (Src homology 2 domain containing) transforming protein 1
- Zebrafish(323818) SHC (Src homology 2 domain containing) transforming protein 1
- dog(490439) SHC (Src homology 2 domain containing) transforming protein 1
- Horse(100063053) SHC (Src homology 2 domain containing) transforming protein 1
- domestic cat(101092911) SHC (Src homology 2 domain containing) transforming protein 1
- chicken(395934) SHC (Src homology 2 domain containing) transforming protein 1
- cow(507196) SHC (Src homology 2 domain containing) transforming protein 1
- sheep(101113548) SHC (Src homology 2 domain containing) transforming protein 1
- naked mole-rat(101717434) SHC (Src homology 2 domain containing) transforming protein 1
- domestic guinea pig(100734561) SHC (Src homology 2 domain containing) transforming protein 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-p66shc Antibody, clone BG8, ,
Espèces réactives
human, mouse
Application
immunocytochemistry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-Pan Shc Antibody, clone 3A12.1, clone 3A12.1, from mouse,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-SHC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-SHC antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-phospho-SHC1 (pTyr349) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse
Application
immunofluorescence
western blot
western blot