Accéder au contenu
Merck

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Synonymes:
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Espèce(s):
Human PTGS2 (5743), Mouse Ptgs2 (19225), Rat Ptgs2 (29527), cow PTGS2 (282023), sheep PTGS2 (443460), Goat PTGS2 (100860905), naked mole-rat Ptgs2 (101704771), Domestic Rabbit PTGS2 (100009248), domestic guinea pig Ptgs2 (100135607), chicken PTGS2 (396451) ...Plus
ID UniProtKB:
P35354, A8K802, Q16876
ID du gène:
  • Human(5743) Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
  • Mouse(19225) prostaglandin-endoperoxide synthase 2
  • Rat(29527) prostaglandin-endoperoxide synthase 2
  • cow(282023) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • sheep(443460) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Goat(100860905) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • naked mole-rat(101704771) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Domestic Rabbit(100009248) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic guinea pig(100135607) prostaglandin-endoperoxide synthase 2
  • chicken(396451) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Horse(791253) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic cat(100126581) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • dog(442942) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Référence du produit
Description
Espèce(s)
RAB1034
Human COX-2 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
240R-1
COX-2 (SP21) Rabbit Monoclonal Antibody, ,
Espèces réactives
human
Application
immunohistochemistry
SAB5702963
Anti-COX2/PTGS2 Antibody, clone 2V7G8, Rabbit Monoclonal, ,
Espèces réactives
mouse
Application
immunohistochemistry
western blot
SAB4502491
Anti-COX2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB5700721
Anti-Cox2 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
HPA001335
Anti-COX2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
T4376
N-p-Tosyl-L-phénylalanine chlorométhyl cétone, ≥97% (TLC), powder,
Espèce(s)
human

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
SML1713
Carprofen, ≥97% (HPLC),
Espèce(s)
human
A8861
Aceclofenac, ≥98% (HPLC),
Espèce(s)
human
1098504
Celecoxib, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1096699
Carprofen, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
32097
Etoricoxib, VETRANAL®, analytical standard,
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
C0858
Cyclooxygenase 2 human, ≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EMU039641
MISSION® esiRNA, targeting mouse Ptgs2,
Espèce(s)
mouse
EHU050311
MISSION® esiRNA, targeting human PTGS2,
Espèce(s)
human