PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
Synonymes:
PDHA, PDHCE1A, PHE1A
Espèce(s):
Human PDHA1 (5160), Mouse Pdha1 (18597), Rat Pdha1 (29554), chicken PDHA1 (418610), domestic cat PDHA1 (101080765), dog PDHA1 (480858), cow PDHA1 (407109), sheep PDHA1 (101110118), domestic guinea pig Pdha1 (100735725), naked mole-rat Pdha1 (101716937)
ID UniProtKB:
ID du gène:
- Human(5160) Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
- Mouse(18597) pyruvate dehydrogenase E1 alpha 1
- Rat(29554) pyruvate dehydrogenase (lipoamide) alpha 1
- chicken(418610) pyruvate dehydrogenase (lipoamide) alpha 1
- domestic cat(101080765) pyruvate dehydrogenase (lipoamide) alpha 1
- dog(480858) pyruvate dehydrogenase (lipoamide) alpha 1
- cow(407109) pyruvate dehydrogenase (lipoamide) alpha 1
- sheep(101110118) pyruvate dehydrogenase (lipoamide) alpha 1
- domestic guinea pig(100735725) pyruvate dehydrogenase (lipoamide) alpha 1
- naked mole-rat(101716937) pyruvate dehydrogenase (lipoamide) alpha 1
- Domestic Rabbit(100357349) pyruvate dehydrogenase (lipoamide) alpha 1
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-phospho-PDHE1-A type I (Ser293) Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
bovine, human, mouse, primate, rat, zebrafish
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho PDHE1-A type I (Ser300) Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
xenopus, bovine, human, mouse, rat, zebrafish
Application
immunocytochemistry
western blot
western blot
Anti-p-PDHA1-Ser232 Antibody, clone 2D5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, horse, human, monkey, mouse, rat, sheep
Application
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
ANTI-PHOSPHO-PDHE1A(S232) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
Anti-PDHA1 Antibody, clone 1B13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, human, monkey, mouse, porcine, rat
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Kits
Référence du produit
Description
Espèce(s)
Pyruvate Dehydrogenase Activity Assay Kit, sufficient for 100 colorimetric tests,
Espèce(s)
rat, mouse, human