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Merck

PDE4C

phosphodiesterase 4C, cAMP-specific

Synonymes:
DPDE1
Espèce(s):
Human PDE4C (5143), Mouse Pde4c (110385), Rat Pde4c (290646), dog PDE4C (609938), domestic cat PDE4C (101086123), cow PDE4C (524624), sheep PDE4C (101111282), naked mole-rat Pde4c (101703048)
ID UniProtKB:
Q08493, B3KTC4, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6
ID du gène:
  • Human(5143) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Mouse(110385) phosphodiesterase 4C, cAMP specific
  • Rat(290646) phosphodiesterase 4C, cAMP-specific
  • dog(609938) phosphodiesterase 4C, cAMP-specific
  • domestic cat(101086123) phosphodiesterase 4C, cAMP-specific
  • cow(524624) phosphodiesterase 4C, cAMP-specific
  • sheep(101111282) phosphodiesterase 4C, cAMP-specific
  • naked mole-rat(101703048) phosphodiesterase 4C, cAMP-specific

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Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
A1755
Aminophylline dihydrochloride hyderate, ≥98%, powder,
Espèce(s)
human
1653004
Theophylline, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
PHL82668
Theophylline, phyproof® Reference Substance,
Espèce(s)
human
PHR1023
Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
1653117
Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
HPA048975
Anti-PDE4C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
SAB1404183
Monoclonal Anti-PDE4C, (N-terminal) antibody produced in mouse, clone 4E5, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence
western blot
SAB1400197
Monoclonal Anti-PDE4C antibody produced in mouse, clone 6A10, ascites fluid,
Espèces réactives
human
Application
ELISA
western blot
HPA054218
Anti-PDE4C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
SML1099
Roflumilast, ≥98% (HPLC),
Espèce(s)
human
SML0517
Amlexanox, ≥98% (HPLC),
Espèce(s)
human
I0157
Ibudilast, ≥99% (HPLC), solid,
Espèce(s)
human
D0633
7-(2,3-Dihydroxypropyl)theophylline, ,
Espèce(s)
human
1231502
Dyphylline, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
SRP0265
PDE4C Active from mouse, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Espèce(s)
mouse
SRP0266
PDE4C1 Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EMU043571
MISSION® esiRNA, targeting mouse Pde4c,
Espèce(s)
mouse
EHU060201
MISSION® esiRNA, targeting human PDE4C,
Espèce(s)
human