NR1I2
nuclear receptor subfamily 1, group I, member 2
Synonymes:
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Espèce(s):
Human NR1I2 (8856), Mouse Nr1i2 (18171), Rat Nr1i2 (84385), Zebrafish nr1i2 (565875), dog NR1I2 (403482), cow NR1I2 (493713), domestic cat NR1I2 (101088355), domestic guinea pig Nr1i2 (100719967), naked mole-rat Nr1i2 (101722589), sheep NR1I2 (101118075)
ID UniProtKB:
ID du gène:
- Human(8856) Summary: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(18171) nuclear receptor subfamily 1, group I, member 2
- Rat(84385) nuclear receptor subfamily 1, group I, member 2
- Zebrafish(565875) nuclear receptor subfamily 1, group I, member 2
- dog(403482) nuclear receptor subfamily 1, group I, member 2
- cow(493713) nuclear receptor subfamily 1, group I, member 2
- domestic cat(101088355) nuclear receptor subfamily 1, group I, member 2
- domestic guinea pig(100719967) nuclear receptor subfamily 1, group I, member 2
- naked mole-rat(101722589) nuclear receptor subfamily 1, group I, member 2
- sheep(101118075) nuclear receptor subfamily 1, group I, member 2
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-NR1I2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-NR1I2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-NR1I2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-PXR Antibody, clone 1F10.1, clone 1F10.1, from mouse,
Espèces réactives
chimpanzee, gorilla, human
Application
western blot
Anti-NR1I2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human, rat
Application
immunofluorescence
western blot
western blot
Cell Lines
Référence du produit
Description
Espèce(s)
Proteins
esiRNA
Référence du produit
Description
Espèce(s)