MAP3K3
mitogen-activated protein kinase kinase kinase 3
Synonymes:
MAPKKK3, MEKK3
Espèce(s):
Human MAP3K3 (4215), Mouse Map3k3 (26406), Rat Map3k3 (303604), naked mole-rat Map3k3 (101704335), domestic guinea pig Map3k3 (100731994), sheep MAP3K3 (101122537), Zebrafish map3k3 (560211), chicken MAP3K3 (419954), domestic cat MAP3K3 (101083633), cow MAP3K3 (508943) ...Plus
ID UniProtKB:
ID du gène:
- Human(4215) Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(26406) mitogen-activated protein kinase kinase kinase 3
- Rat(303604) mitogen activated protein kinase kinase kinase 3
- naked mole-rat(101704335) mitogen-activated protein kinase kinase kinase 3
- domestic guinea pig(100731994) mitogen-activated protein kinase kinase kinase 3
- sheep(101122537) mitogen-activated protein kinase kinase kinase 3
- Zebrafish(560211) mitogen-activated protein kinase kinase kinase 3
- chicken(419954) mitogen-activated protein kinase kinase kinase 3
- domestic cat(101083633) mitogen-activated protein kinase kinase kinase 3
- cow(508943) mitogen-activated protein kinase kinase kinase 3
- Horse(100064751) mitogen-activated protein kinase kinase kinase 3
- dog(480481) mitogen-activated protein kinase kinase kinase 3
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-MAP3K3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Anti-MAP3K3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-MAP3K3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-MAP3K3 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
proximity ligation assay
western blot
western blot
Monoclonal Anti-MAP3K3 antibody produced in mouse, clone 1H3, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
western blot
Proteins
Référence du produit
Description
Espèce(s)
MEKK3, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human