GRM2
glutamate receptor, metabotropic 2
Synonymes:
GLUR2, GPRC1B, MGLUR2, mGlu2
Espèce(s):
Human GRM2 (2912), Mouse Grm2 (108068), Rat Grm2 (24415), chicken GRM2 (427575), dog GRM2 (484751), domestic cat GRM2 (101098611), cow GRM2 (519904), Horse GRM2 (100052178), sheep GRM2 (101116870), domestic guinea pig Grm2 (100720736)
ID UniProtKB:
ID du gène:
- Human(2912) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(108068) glutamate receptor, metabotropic 2
- Rat(24415) glutamate receptor, metabotropic 2
- chicken(427575) glutamate receptor, metabotropic 2
- dog(484751) glutamate receptor, metabotropic 2
- domestic cat(101098611) glutamate receptor, metabotropic 2
- cow(519904) glutamate receptor, metabotropic 2
- Horse(100052178) glutamate receptor, metabotropic 2
- sheep(101116870) glutamate receptor, metabotropic 2
- domestic guinea pig(100720736) glutamate receptor, metabotropic 2
- naked mole-rat(101722804) glutamate receptor, metabotropic 2
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Small Molecule - Agonist
Small Molecule - Antagonist
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-mGluR2/3 Antibody, Upstate®, from rabbit,
Espèces réactives
human, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-GRM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-MGLUR2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Metabotropic Glutamate Receptor 2 Antibody, Chemicon®, from rabbit,
Espèces réactives
human
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-GRM2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espèce(s)
rat, human
Small Molecule - Ligand
Référence du produit
Description
Espèce(s)
Small Molecule - Mixed Agonist/Antagonist
Référence du produit
Description
Espèce(s)
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espèce(s)
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espèce(s)
rat, human
esiRNA
Référence du produit
Description
Espèce(s)