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Merck

FDPS

farnesyl diphosphate synthase

Synonymes:
FPPS, FPS
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2224) Summary: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
  • Mouse(110196) farnesyl diphosphate synthetase
  • Rat(83791) farnesyl diphosphate synthase
  • sheep(101119093) farnesyl diphosphate synthase
  • domestic guinea pig(100717025) farnesyl diphosphate synthase
  • naked mole-rat(101721614) farnesyl diphosphate synthase
  • Zebrafish(552997) farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
  • cow(281156) farnesyl diphosphate synthase
  • Horse(100063641) farnesyl diphosphate synthase
  • domestic cat(101086533) farnesyl diphosphate synthase
  • dog(480129) farnesyl diphosphate synthase
  • chicken(425061) farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-FDPS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Alendronate sodium trihydrate, ≥97% (NMR), powder,
Espèce(s)
human
Alendronate sodium, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Alendronate Sodium, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Ibandronate sodium monohydrate, ≥97% (NMR), solid,
Espèce(s)
human
Sodium alendronate trihydrate, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Fdps,
Espèce(s)
mouse
MISSION® esiRNA, targeting human FDPS,
Espèce(s)
human