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Merck

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Synonymes:
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Espèce(s):
Human CDKN1B (1027), Mouse Cdkn1b (12576), Rat Cdkn1b (83571), chicken CDKN1B (374106), dog CDKN1B (403429), cow CDKN1B (512613), domestic cat CDKN1B (493958), chicken CDKN1B (769872), naked mole-rat Cdkn1b (101698721), domestic guinea pig Cdkn1b (100729359) ...Plus
ID UniProtKB:
P46527, Q16307, Q5U0H2, Q9BUS6
ID du gène:
  • Human(1027) Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
  • Mouse(12576) cyclin-dependent kinase inhibitor 1B
  • Rat(83571) cyclin-dependent kinase inhibitor 1B
  • chicken(374106) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • dog(403429) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cow(512613) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic cat(493958) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • chicken(769872) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • naked mole-rat(101698721) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic guinea pig(100729359) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • sheep(100127219) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • Domestic Rabbit(100009037) cyclin-dependent kinase inhibitor 1B (p27, Kip1)

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Antibodies

Référence du produit
Description
Espèces réactives
Application
SAB4504200
Anti-phospho-p27 Kip1 (pThr198) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
WH0001027M1
Monoclonal Anti-CDKN1B antibody produced in mouse, clone 4B4-E6, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
06-996
Anti-phospho-Kip1 (Thr187) Antibody, Upstate®, from rabbit,
Espèces réactives
human, mouse, rat
Application
western blot
06-445
Anti-Kip1 (p27) Antibody, Upstate®, from rabbit,
Espèces réactives
human, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
427M-9
p27Kip1 (SX53G8) Mouse Monoclonal Antibody, ,
Espèces réactives
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
R7772
Roscovitine, ≥98% (TLC),
Espèce(s)
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Espèce(s)
human, rat

Proteins

Référence du produit
Description
Espèce(s)
SRP5109
p27KIP1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human
23-024-M
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EMU028461
MISSION® esiRNA, targeting mouse Cdkn1b,
Espèce(s)
mouse
EHU025821
MISSION® esiRNA, targeting human CDKN1B,
Espèce(s)
human