CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Synonymes:
CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Espèce(s):
Human CDKN1A (1026), Mouse Cdkn1a (12575), Rat Cdkn1a (114851), sheep CDKN1A (100302083), domestic guinea pig Cdkn1a (100720449), naked mole-rat Cdkn1a (101710552), Zebrafish cdkn1a (100151416), cow CDKN1A (513497), domestic cat CDKN1A (493943), dog CDKN1A (474890)
ID UniProtKB:
ID du gène:
- Human(1026) Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
- Mouse(12575) cyclin-dependent kinase inhibitor 1A (P21)
- Rat(114851) cyclin-dependent kinase inhibitor 1A
- sheep(100302083) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- domestic guinea pig(100720449) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- naked mole-rat(101710552) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- Zebrafish(100151416) cyclin-dependent kinase inhibitor 1A
- cow(513497) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- domestic cat(493943) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- dog(474890) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-p21 Antibody, clone 5G7, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-p21/WAF1/Cip1 Antibody, Upstate®, from mouse,
Espèces réactives
human, mouse
Application
immunoprecipitation (IP)
western blot
western blot
p21WAF1 (DCS-60.2) Mouse Monoclonal Antibody, ,
Espèces réactives
human
Application
immunohistochemistry
Anti-p21WAF1 (Ab-1) Mouse mAb (EA10), liquid, clone EA10, Calbiochem®,
Espèces réactives
human
Application
Anti-P21 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
western blot
Small Molecule - Inhibitor
Proteins
Référence du produit
Description
Espèce(s)
p21CIP1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human