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1707839

USP

Valacyclovir hydrochloride

United States Pharmacopeia (USP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C13H20N6O4 · HCl
CAS Number:
Molecular Weight:
360.80
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:

grade

pharmaceutical primary standard

API family

valacyclovir

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CC(C)[C@H](N)C(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12

InChI

1S/C13H20N6O4.ClH/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H/t8-;/m0./s1

InChI key

ZCDDBUOENGJMLV-QRPNPIFTSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Valacyclovir is a prodrug of acyclovir. It is an L-valyl ester and works against herpes simplex virus type and varicella zoster virus.

Application

It was used as reference standard for the quantification of valayclovir and its metabolite, from human plasma using LC/ESI-MS method.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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UV spectrophotometric method for the estimation of valacyclovir hcl in tablet dosage form.
Ganesh, M., et al.
Journal of Chemistry, 6.3, 814-818 (2009)
Selective and rapid liquid chromatography/negative-ion electrospray ionization mass spectrometry method for the quantification of valacyclovir and its metabolite in human plasma.
Kasiari M
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 864(1-2), 78-86 (2008)
Shlomit Schaal et al.
JAMA ophthalmology, 132(7), 881-882 (2014-04-20)
Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history
Mary J Burton et al.
The American journal of the medical sciences, 348(6), 455-459 (2014-08-28)
We performed a pilot study examining the safety and tolerability of valacyclovir in veterans with herpes simplex virus type 2 and hepatitis C virus (HCV) coinfection. We performed a randomized double-blind, placebo-controlled, crossover clinical trial in U.S. veterans with genotype
Laurence Le Cleach et al.
The Cochrane database of systematic reviews, 8(8), CD009036-CD009036 (2014-08-05)
Genital herpes is caused by herpes simplex virus 1 (HSV-1) or 2 (HSV-2). Some infected people experience outbreaks of genital herpes, typically, characterized by vesicular and erosive localized painful genital lesions. To compare the effectiveness and safety of three oral

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