1302101

Guanfacine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide
• Empirical Formula (Hill Notation): C₉H₉Cl₂N₃O · HCl
• CAS Number: 29110-48-3
• Molecular Weight: 282.55
• MDL number: MFCD00798230
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749977
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: guanfacine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
• InChI: 1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
• InChI key: DGFYECXYGUIODH-UHFFFAOYSA-N
• Gene Information: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

• Reduction of Anxiety-related Reactivity in Primates: Guanfacine hydrochloride mediates anxiety-related reactivity and reduces associated agonistic behavior in two pigtail macaques, showcasing its potential for managing stress and aggression in clinical and veterinary settings (Hopper et al., 2024).


• Enhanced Analgesia for Surgical Procedures: The synergistic interaction of guanfacine with lidocaine enhances cutaneous analgesia, indicating its utility in improving pain management strategies, particularly in surgical environments (Chou et al., 2024).

Biochem/physiol Actions

α-2 noradrenergic receptor agonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable