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T122

Sigma-Aldrich

Telenzepine dihydrochloride hydrate

solid, ≥98% (HPLC)

Synonym(s):

4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H22N4O2S · 2HCl · xH2O
CAS Number:
147416-96-4
Molecular Weight:
443.39 (anhydrous basis)
MDL number:
MFCD11045947
UNSPSC Code:
12352200
PubChem Substance ID:
24277875
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

white

solubility

H2O: >10 mg/mL

SMILES string

O.Cl.Cl.CN1CCN(CC1)CC(=O)N2c3ccccc3NC(=O)c4csc(C)c24

InChI

1S/C19H22N4O2S.2ClH.H2O/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22;;;/h3-6,12H,7-11H2,1-2H3,(H,20,25);2*1H;1H2

InChI key

HZWCRPGARSMPNS-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

Application

Telenzepine dihydrochloride hydrate was used to study M1 muscarinic receptor-mediated signaling in juvenile rat hippocampus and rat urinary bladder.

Biochem/physiol Actions

Telenzepine is an analog of pirenzepine and inhibits the secretion of gastric acid. It is an antagonist to M1-receptor and targets the oxyntic gastric glands and the salivary glands.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
122M4616V
037K4611
046K4611
024K4613

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K Kawashima et al.
General pharmacology, 21(1), 17-21 (1990-01-01)
1. Effects of three muscarinic antagonists on electrically evoked ACh release and contractile response were investigated in longitudinal muscle strips of guinea-pig ileum suspended in an organ-bath and superfused with Krebs solution. ACh release was determined by a specific radioimmunoassay.
G Bertaccini et al.
Pharmacological research, 21(4), 339-352 (1989-07-01)
The control of gastric secretion may be obtained by means of several pharmacological compounds: histamine H2 receptor antagonists and anticholinergics are so far the most widely employed drugs in pharmacological experiments and in clinical practice. The H2 blockers are able
G Coruzzi et al.
Archives internationales de pharmacodynamie et de therapie, 302, 232-241 (1989-11-01)
The new M1-receptor antagonist telenzepine has been studied for its antisecretory effect in different in vitro and in vivo experimental models in comparison with pirenzepine. Telenzepine was found to be from 3 to 10 times more potent than pirenzepine in
Turgut Emrah Bozkurt et al.
Pharmacological research, 59(5), 300-305 (2009-05-07)
We have investigated the muscarinic receptor subtype(s) mediating the release of urinary bladder-derived relaxant factor that is demonstrated by a coaxial bioassay system. Acetylcholine-induced relaxation of a precontracted anococcygeus muscle mounted within the bladder was considered as an evidence for
A M Rosati et al.
Brain research, 815(2), 185-191 (1999-01-08)
Binding studies were used to assess the changes in affinity and/or number of M1 muscarinic receptors in hippocampi from juvenile rats chronically deprived of NGF. NGF deprivation was obtained by implanting into right ventricle at postnatal day 2 (P2) hybrydoma
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