SRP8010

GPX1 human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

• Synonym(s): Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1
• CAS Number: 1451392-36-1
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• tag: His tagged
• Assay: >90% (SDS-PAGE)
• form: lyophilized
• mol wt: ~25 kDa by SDS-PAGE
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: <1 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: P07203
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... GPX1(2876)

Description

General description

GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.

Biochem/physiol Actions

GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.

Physical form

Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable