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SML0379

Sigma-Aldrich

Nodinitib-1

≥98% (HPLC)

Synonym(s):

1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, CID-1088438, ML130

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About This Item

Empirical Formula (Hill Notation):
C14H13N3O2S
CAS Number:
799264-47-4
Molecular Weight:
287.34
MDL number:
MFCD04322367
UNSPSC Code:
12352200
PubChem Substance ID:
329825379
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

NC1=NC2=C(N1S(C3=CC=C(C)C=C3)(=O)=O)C=CC=C2

InChI

1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)

InChI key

SRFABRWQVPCPRG-UHFFFAOYSA-N

Biochem/physiol Actions

Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yi-Hsin Fan et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(48), E7818-E7827 (2016-11-20)
Induction of nucleotide-binding oligomerization domain 2 (NOD2) and downstream receptor-interacting serine/threonine-protein kinase 2 (RIPK2) by human cytomegalovirus (HCMV) is known to up-regulate antiviral responses and suppress virus replication. We investigated the role of nucleotide-binding oligomerization domain 1 (NOD1), which also
Miao Wang et al.
Journal of neuroinflammation, 17(1), 364-364 (2020-12-03)
Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major factor contributing to the high mortality of intracerebral haemorrhage (ICH). Nucleotide-binding oligomerization domain 1 (NOD1)/receptor-interacting protein 2 (RIP2) signalling has been reported to
Myra G Dela Pena-Ponce et al.
PloS one, 12(8), e0183324-e0183324 (2017-08-17)
Epidemiologic studies have reported an inverse relationship between childhood Helicobacter pylori infection and development of allergic asthma. Because lung epithelium plays an important role in allergic asthma pathogenesis, we hypothesized that H. pylori may directly influence airway epithelial cell innate
Jiarui Bi et al.
Scientific reports, 7(1), 4411-4411 (2017-07-02)
Periodontal diseases manifest by the formation of deep pockets between the gingiva and teeth where multispecies bacterial biofilms flourish, causing inflammation and bone loss. Epithelial cell receptor αvβ6 integrin that regulates inflammation by activating the anti-inflammatory cytokine transforming growth factor-β1
Wendy Chi et al.
PloS one, 9(5), e97675-e97675 (2014-05-16)
Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to inflammation, but nutrient intake and obesity are also associated with altered bacterial load in metabolic tissues (i.e. metabolic endotoxemia).

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