SML0340

Hydroxy-Dynasore

≥98% (HPLC)

• Synonym(s): 3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide, 3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
• Empirical Formula (Hill Notation): C₁₈H₁₄N₂O₅
• CAS Number: 1256493-34-1
• Molecular Weight: 338.31
• MDL number: MFCD23704787
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825345
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: faintly yellow to dark yellow
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Oc1cc(O)c(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
• InChI: 1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+
• InChI key: UAXHPUSKEWEOAP-DJKKODMXSA-N

Description

Biochem/physiol Actions

Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin A heavy chain binding domain (BoNT/A-Hc). Apparently, Hydroxy-Dynasore prevents dynamin-mediated fission of endocytic vesicles from the plasma membrane.

Other Notes

Air sensitive.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable